He was born Milton Campbell in a modest sharecroppers home on the outskirts of Inverness, Mississippi, on September 7th 1934. As a child, he was drawn by a very popular radio shows of the day (and still is): The Grand Ole Opry. He found an early connection to Country and western music and later fused it with the other two predominant musical influences of the Mississippi Delta: Gospel & Blues. A youthful “Little” Milton began studying what he heard and practiced; mastering songs and reciting them, no matter what the style or difficulty. By his early teens, he was performing in local clubs and bars across the Delta.

As Milton grew into a young man, he didn't waste any time learning the ropes or absorbing all the musical possibilities that existed at the time. He played street corners, alleys, dives, you name it, carefully developing his craft and attracting the attention of established acts and local record labels. By the time Ike Turner introduced Milton to Sam Phillips of Sun Records in the early 50's, he was a young but seasoned performer with a momentous live show that created a buzz in every town he played. His debut single Beggin' My Baby was recorded and released at the same time Sam Phillips was molding the sound of another unknown talent from Mississippi: Elvis Presley.

After recording a series of sides at Sun without great fanfare, Milton moved to East St. Louis’ Bobbin Records, where his recording career flourished. He also became Bobbin's A&R chief and working partner to its owner, Bob Lyons. During this era, Milton signed such artists as Albert King and Fontella Bass to the label. Most importantly, he cut his own first hit, I'm A Lonely Man, in 1958.

At Stax, he joined a virtual who’s who of influential black recording artist of the day including Isaac Hayes, Rufus & Carla Thomas, Booker T. & The M.G.'s, Albert King and, coincidentally, another future Malaco star, the late Johnnie Taylor. Milton’s legend only grew at Stax, where from 1971 through 1975, he stacked up more mega hits…including Walking The Back Streets and Cryin and That's What Love Will Make You Do.

When Stax filed bankruptcy in 1975, Milton joined TK/Glades Records in Miami, then home to such artist as Betty Wright, K. C. & The Sunshine Band and Latimore. There, he racked up another charted hit, Friend of Mine. But the Glade label also went out of business. Consequently, in 1983, he released his only album for MCA, Age Ain't Nothin But A Number. The title cut was an instant-charted hit.

In 1984, Little Milton united with Malaco Records and began the longest professional association of his career. He continued his exceptional vocal and guitar styles and quickly became one of Malaco's biggest selling artists. He swept up such honors as the 1988 W. C. Handy Blues Entertainer of the Year Award and the 2000 Grammy award nomination. He also was inducted into the Blues Hall of Fame.

Over the years, Malaco has released 14 of Little Milton's albums, including the critically acclaimed, Billboard blues smash hit Cheatin Habit. Cheatin Habit followed his wildly successful Little Milton's Greatest Hits compilation. Some of Little Milton's Malaco cuts that have become American blues standards include Annie Mae's Cafe, The Blues is Alright, Little Bluebird, Room 244, I Was Trying Not to Break Down, Catch You on Your Way Down, Murder on Your Hands, and Comeback Kind of Love.

The year 2001 marked a successful run of sold out shows in the United States and Europe and the release of Feel It. Malaco doubled back in September, 2002, with the release CD number 14, Guitar Man. It's celebrated cuts include Guitar Man, Still Some Meat Left on this Bone, and Milton's soulful rendition of My Way.

In 2005, after more than a half century after his early SUN recordings, Little Milton made his debut on the TELARC label with the release of THINK OF ME, a mesmerizing CD consisting of a dozen tracks distilling a lifetime of rich guitar skills, compelling vocals and deft songwriting all wrapped into a single high powered package. It would be his last studio recording.
The man who made the THE BLUES IS ALRIGHT a national anthem with blues enthusiasts around the globe, passed away on August 4, 2005, after suffering a massive brain stroke. Hundreds of family, friends, and fans attended his memorial on August 10, 2005 in South Haven, Mississippi in a final farewell to "MR. C".